Please add an event date in the future.
Directory
- Published by
- Mikls Antal
- Organisation / Company
- University of Debrecen
- Address 1
- Department of Anatomy, Histology and Embryology
- Address 2
- Faculty of Medicine
- Address 3
- Medical and Health Science Center
- Street Nr. / P.O. Box
- Nagyerdei krt. 98
- Postcode
- H-4032
- City
- Debrecen
- Country
- Hungary
- Telephone (Office)
- 36 52 416392
- Fax (Office)
- 36 52 432290
- E-Mail (Office)
- Website
- http://www.anat.dote.hu
- Votes
- 0
- Visited
- 153
Long-lasting changes in nociceptive-processing circuits of the spinal dorsal horn evoked by tissue or nerve injury are thought to critically contribute to conditions of chronic pain and hyperalgesia. Mechanisms underlying this activity-evoked plasticity are yet poorly understood. They involve complex changes in molecular architecture, synaptic efficacy, intrinsic neuronal firing and network organization of neural microcircuits in the superficial spinal dorsal horn.
To acquire a more exhaustive understanding of fundamental aspects of the structural, functional, chemical organization and possible mechanisms of activity evoked plasticity of neural microcircuits representing the first relay station in pain processing, we study the synaptic relations, morphological, physiological and neurochemical properties of neural networks in the superficial spinal dorsal horn by using a combination of in vitro and in vivo physiological, high-resolution neuroanatomical and molecular biological techniques at the molecular, cellular and networks levels. In addition to studying the nociceptive and antinociceptive mechanisms under normal conditions, we also intend to elucidate how physiological, morphological and neurochemical properties of pain-processing neural networks in the spinal dorsal horn may change in inflammatory and neuropathic pain states. With this integrative interdisciplinary research, we would also like provide new insights into fundamental mechanisms of activity-evoked neural plasticity, chronic pain and hypreralgesia, and assist in developing effective therapeutic strategies and treatments for chronic pain syndromes.
Directory 